Rapid sequence intubation in the hospital setting is performed by a provider to gain rapid airway control while decreasing the risk of aspiration. The administration of neuromuscular blocking agents (NMBAs) is performed by a nurse during rapid sequence intubation. Following an extensive literature review, the literature suggests when appropriate dosages were used, rocuronium proved to provide similar intubating conditions to Succinylcholine. After reviewing many journals about the practice of RSI there are two main NMBAs used, Rocuronium and Succinylcholine. Understanding the use of different medications and their effects is an important part of the nursing role. The use of different NMBAs can lead to different patient outcomes. By understanding the effects of each medication, the nurse will be able to effectively render care and monitor for potential adverse events. The purpose of researching this topic is to explore the potential for improved patient outcomes when employing different medications during RSI. While succinylcholine remains the predominant choice among many providers due to its rapid onset and short duration of action, it is associated with several side effects, such as hyperkalemia and malignant hyperthermia. In contrast, rocuronium presents as an alternative because it lacks significant side effects and has an effective reversal agent with Sugamadex. If rocuronium can provide comparable intubation conditions to succinylcholine while offering a safer profile and a reversal agent, it may lead to fewer complications and overall, a higher level of patient safety.The exploration of these medications highlights the role that nurses play in optimizing patient safety and advocating for the best possible outcomes for their patients.