Global Health Nursing is concerned with resolving health issues globally, that is, ensuring the right to health to protect oneself and others against illness. This special issue is at the cutting edge of the conversation at the 4th Edition World Nursing Science Conference 2025, where we discuss the central role of nurses in solving some of the health challenges constraining the world now, such as pandemics, infectious disease spread, and vaccination programs. This conference will also serve as a place for the professionals of global health nursing among marginal communities, the health of migrants, and disaster relief services. Let us join the ranks of healthcare professionals in closing these gaps and improving population health by getting involved in advocacy and culturally sensitive care.